Executive Director/ Senior Director – Global Operational Excellence Dublin, Ireland Hybrid

Job description

Back to Jobs Dublin BioMarin Pharmaceutical Who We Are BioMarin is a leading rare disease biotechnology company focused on genetically defined conditions. Guided by our purpose to develop medicines that make a profound impact on people’s lives, our global teams have delivered a portfolio of therapies since our founding in 1997. Our revolutionary treatments for conditions like achondroplasia (the most common form of dwarfism), PKU (phenylketonuria), CLN2, a form of Batten disease, and a number of forms of MPS (mucopolysaccharidosis) offer new possibilities for patients and families who previously had few, if any, available options. More recently, with the close of the Amicus acquisition, our portfolio has expanded to include therapies for Fabry disease and Pompe disease, expanding our ability to reach more people living with rare genetic conditions. Our success comes from our unwavering commitment to excellence, our deep understanding of patient needs, our scientific expertise, and our world-class manufacturing capabilities. At the heart of BioMarin is a dedicated team of the brightest minds in the industry working together to deliver innovative therapies to patients and families around the world. About Technical Operations BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin’s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. Who We Are BioMarin is a leading rare disease biotechnology company focused on genetically defined conditions. Guided by our purpose to develop medicines that make a profound impact on people’s lives, our global teams have delivered a portfolio of therapies since our founding in 1997. Our revolutionary treatments for conditions like achondroplasia (the most common form of dwarfism), PKU (phenylketonuria), CLN2, a form of Batten disease, and a number of forms of MPS (mucopolysaccharidosis) offer new possibilities for patients and families who previously had few, if any, available options. More recently, with the close of the Amicus acquisition, our portfolio has expanded to include therapies for Fabry disease and Pompe disease, expanding our ability to reach more people living with rare genetic conditions. Our success comes from our unwavering commitment to excellence, our deep understanding of patient needs, our scientific expertise, and our world-class manufacturing capabilities. At the heart of BioMarin is a dedicated team of the brightest minds in the industry working together to deliver innovative therapies to patients and families around the world. About Technical Operations BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin’s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. Executive Director/ Senior Director – Global Operational Excellence Location: Dublin or Cork, Ireland Hybrid role 2 days per week onsite Role Summary The Executive Director Global Operational Excellence owns the single global TOPS improvement method, operating system and capability to apply it. Reporting to the VP, TOPS Digital Strategy & Operational Excellence, the role builds a network that can improve itself and deliver sustained operational and financial benefits while protecting quality and reliable patient supply. Together with Data Science, Analytics & AI and Digital Strategy & Value Delivery, the role works across Frame, Baseline, Simplify, Digitize and Prove. The approach is People, then Process, then Technology: remove waste and standardize before digitizing. Data Science, Analytics & AI discovers evidenced value; OpEx strengthens methods, people and processes; Digital Strategy & Value Delivery prioritizes and commissions digital change, adoption and network scale. As the global owner of OpEx methods and capability, this leader connects central priorities with site accountability, develops practitioners and leaders, and contributes evidence and time-bound capacity to cross-pillar pursuits. Success means adopted, sustained and measured operating results, not technology go-live alone. Key Responsibilities Own the BioMarin/TOPS operational excellence roadmap, structure, content, development and maturity Deploy consistent Lean and Six Sigma standards across internal and external operations where applicable, with practical coaching for site teams and leaders across the network. Own global capability-building and knowledge-management strategy and processes across all OpEx areas, including reusable learning, accreditation, certification and assessment standards and materials, central belt certification, Lean training and the Opex Leadership Coaching Programme. Target operational losses using data-based baselines, disciplined strategic projects and tested people/process alternatives. Assess site maturity and practitioner competence, verify improvements, and publish comparable maturity, loss-reduction and sustained results with linked capability plans. Lead complex cross-functional root-cause problem-solving, address systemic issues and verify improvement effectiveness. Standardize, document and replicate successful improvements, sharing proven practices and lessons across the network. Train, certify and mentor site improvement practitioners, including those beyond direct reports, to apply the common methodology effectively. Work as a peer to the TOPS leaders of Data Science, Analytics & AI and Digital Strategy & Value Delivery to successfully identify, prioritize and deliver value against TOPS Strategic objectives (eg. COGS, DIOH) Partner with Digital Strategy & Value Delivery and DTA on systems enhancements, ensuring process simplification and standardization precede technology changes. Lead the central OpEx team setting role levels, development pathways, objectives and the technical bar within a culture of coaching, accountability and learning. Develop site Master Black Belts and Lean Masters for local support and continuity, retaining local reporting for site leads, belts, analysts and stewards with dotted-line links to central standards Deploy OpEx improvement resources against agreed portfolio priorities, aligning capacity and capability with improvement needs. Apply appropriate AI tools to improve Lean, 6-sigma methodologies and effectiveness Use trusted operational analytics, process mining and predictive insights with Data Science, Analytics & AI to identify evidenced opportunities Stakeholder Engagement & Change Leadership Embed improved behaviours and standard work into daily routines, with local and receiving-function ownership to sustain adoption. KPIs & Metrics: This role will influence: Capability & Maturity Metrics Adoption, Sustainment & Network Replication Metrics Operational Loss Reduction & Performance Metrics Verified Financial Benefit Metrics Portfolio Contribution & Delivery Metrics Quality & Patient Supply Metrics Qualifications Required: Degree in engineering, science, operations or a related discipline. Demonstrated multi-site manufacturing OpEx leadership, ideally in a regulated environment. Master Black Belt certification or equivalent depth, with the credibility and judgment to define improvement methodology and competent application. Experience developing, assessing and certifying improve