Senior Associate Scientist, In Vivo Pharmacology, Oncology Discovery Biology

Job description

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities. Position Summary: The successful candidate will join the Oncology Discovery Pharmacology and In Vivo Biology group at Bristol-Myers Squibb in Cambridge, MA and aid in the advancement of early-stage therapeutics in Oncology TRC. This role provides an opportunity to work on cutting-edge immuno-oncology programs, including T cell engager platforms, and to directly impact early-stage therapeutic development. The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities. The candidate will be expected to effectively collaborate with colleagues in Discovery Oncology, protein engineering/antibody development, DMPK and translational group. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders. Position Responsibilities: In the role as a Senior Associate Scientist within In Vivo Discovery Oncology, the ideal candidate will: Experience in conducting mouse in vivo pharmacology experiments, including but not limited to model development, tumor implantation, dosing via IV, IP, SC, IT, IM, and PO routes, tumor measurements, health monitoring, tissue sampling by tail vessel micro-sampling, cardiac puncture and tissue/tumor collection at necropsy including fixation, freezing and tissue disaggregation to support ex vivo analyses. Collaborate with the team to conduct in vivo efficacy and PK/PD studies and experiments supporting the development of new pharmacology models. Independently execute end-to-end flow cytometry workflows, encompassing panel design and establishment, multiparametric profiling of blood, tumor, and lymphoid tissues, downstream data analysis, and clear communication of results to cross-functional teams. Isolate PBMC and primary T cells from Leukopaks and functionally characterize them using cell-based assays. Accurately maintain proper scientific documentation associated with pharmacology studies in an electronic lab notebook. Effectively communicate and present summaries of research results to team members or to a multidisciplinary team of researchers. This position is located in Cambridge, MA. Experience = Basic Qualifications: Bachelor’s Degree 4+ years of academic and / or industry experience Or Master’s Degree 2+ years of academic and / or industry experience Preferred Qualifications: A B.S. with 2-7 years relevant industry or comparable academic experience and a clearly demonstrated in vivo and ex vivo oncology skill sets are required. Experience with subcutaneous syngeneic and xenograft tumor models is required; experience with orthotopic, chemically induced mouse models, GEMMs, and PDx models are all preferred. Competency in murine dosing IV, IP, SC & PO, is required; intra-tumor and IM is preferred. Rodent surgical experience is a plus. Proficiency in cell culture, passaging and harvesting, preparing adherent and suspension mammalian cells for subcutaneous and intravenous implantation is required. Experience in independently processing blood samples, harvesting and disaggregating tumors, spleen, and lymph nodes, and preparing samples for FACS analysis. Experienced in setting up basic FACS multichannel panels (5-6 color) and routinely profile tumors, blood and lymphoid organs by Flow cytometric analysis. Expected to analyze FACS data and present the analysis to the team. Familiar with cytokine profiling studies and analysis by MSD & Luminex methods. Proficiency in utilizing software such as GraphPad Prism™, electronic notebooks, Microsoft office etc. for data analysis and figure generation is required. Excellent organizational skills and a detail-oriented approach to the execution of experiments and record keeping is a requirement. Strong interpersonal skills with the ability to interact effectively with peers and management is required. #LI-Onsite If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: Cambridge Crossing: $105,040 - $127,287 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/. Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include: Health Coverage: Medical, pharmacy, dental, and vision care. Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. ​Work-life benefit