Scientist Nucleic Acids Computational Biology

Job description

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. BMS Launches to Advance New Frontiers of Science with the Next Generation of Innovative RNA Medicines! BMS is committed to enhancing global health by unleashing the full potential of RNA medicines to treat human disease in ways that were not previously possible. To achieve this vision, BMS is developing a first-in-kind RNA platform that integrates both established and emerging technologies and delivery mechanisms, excluding RNAi. The platform is engineered to extend the durability and half-life of BMS’s novel RNA therapeutics and to broaden their delivery to a wider range of cell types and tissues. As BMS’s RNA platform grows, it will continue to invest in expanding its platform capabilities and underlying technologies. Leveraging state-of-the-art RNA and novel delivery technologies, Orbital plans to build an expansive portfolio targeting a broad spectrum of human diseases, with initial focus areas including vaccines, immunomodulation, protein replacement, and regenerative medicine. JOB SUMMARY We are seeking a highly motivated and innovative scientist to drive advances at the interface of RNA biology, computational modeling, and machine learning. In this role, you will design and implement cutting-edge computational approaches to uncover RNA structure–function relationships and to support discovery and development programs across the organization. You will work with complex datasets and build computational tools that provide high-throughput, data-driven insights to accelerate next-generation mRNA medicines. The ideal candidate has a strong foundation in RNA biology, is proficient with RNA secondary structure analysis tools, and has hands-on programming experience in languages such as Python or R. You will work extensively in cloud-based, high-performance computing environments and apply modern software engineering practices to deliver robust, scalable, and well-documented computational solutions. This is a highly collaborative role, requiring close partnership with both wet-lab and dry-lab teams. You will manage multiple dynamic projects, help shape scientific strategy, and clearly communicate findings to diverse stakeholders. A strong track record of impactful research—demonstrated by publications or patent contributions—is strongly preferred. If you excel in a fast-paced, interdisciplinary environment and are excited to push the boundaries of computational RNA science, we would love to hear from you. RESPONSIBILITIES Build and implement custom mRNA optimization strategies to fine tune expression, stability, and immunogenicity, and function of the RNA payload. Innovate on mRNA designs by utilizing scientific literature to implement novel design principles. Collaborate within the RNA sciences team to generate and analyze NGS data from RNA structure probing and other RNA biology-directed experiments such as SHAPE-MaP, DMS-MaP, ribosome profiling, RIP-seq etc. Lead cross‑functional collaboration with experimental biologists, molecular biologists, and therapeutic project teams to design studies, set experimental priorities, and validate computational discoveries. Basic Qualifications Bachelor's Degree 5+ years of academic / industry experience Or Master's Degree 3+ years of academic / industry experience Or PhD No experience required Preferred Qualifications Ph.D. +1 years in Computational Biology, Physics, Computer Sciences or related field. Experience with diverse RNA sequencing modalities beyond standard RNA-seq (e.g., ribosome profiling, CLIP-seq, single-cell RNA-seq, SHAPE-seq, spatial transcriptomics) Experience in applying AI/ML models to NGS datasets to elucidate RNA biology Utilization of computational modeling to evaluate nucleic acid functions required Ability to dissect RNA secondary structure prediction concepts and computational tools highly preferred Experience with one or more programming or scripting languages such as Python and R Experience with cloud computing platforms and high-performance computing environments All eligible employees receive a competitive package that includes: compensation, discretionary bonus, Incentive Stock Options, the opportunity to participate in the Company’s 401k plan, health, dental, and vision benefits, life and disability insurance benefits, voluntary benefits, non-accrual paid time off, company shut down for holidays, and free parking and the opportunity to work in a state of the art building at Cambridge! We value diversity and do not discriminate based on race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform critical job functions, and to receive other benefits and privileges of employment. Please contact Human Resources to request an accommodation. BMS Human Resources leads recruitment and employment for the Company. Unsolicited resumes submitted to the Company from recruiters do not constitute any type of relationship between the recruiter and/or recruiting agency and does not obligate the Company to pay fees should we hire from those resumes. We ask that external recruiter and/or agencies not contact or present candidates directly to our hiring manager or employees. We look forward to your application! If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: Cambridge - MA - US: $141,150 - $171,042 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/. Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include: Health Coverage: Medical, pharmacy, dental, and vision care. Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. ​Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid nat