Associate Scientist, Pharmacology

Job description

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/ RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals Associate Scientist, Pharmacology Job Description This laboratory-based role offers an exciting opportunity to advance novel radiopharmaceutical therapies from bench to bedside. The Associate Scientist will participate in discovery research by conducting in vivo experiments and managing vivarium duties, including experiment design, execution, tissue collection, and data analysis. The role also includes cross-functional collaboration with teams in translational research, medicinal chemistry, and other scientific disciplines. The successful candidate will receive mentorship from senior scientists and must adhere strictly to radiation safety protocols. Key Responsibilities Design and execute in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, therapeutic efficacy, and durability of response across various treatment modalities, including radiopharmaceutical agents. Perform essential in vivo procedures: cell culture, tumor cell and PDX fragment implantation, sampling, dosing (IV, SC, IP, PO), tumor and body weight monitoring, and necropsy. Analyze and interpret experimental data independently; present findings at project team meetings, departmental reviews, and company-wide forums. Work with radioactive materials in strict compliance with institutional and federal radiation safety protocols. Support laboratory operations, including inventory management, equipment maintenance, and ensure strict compliance with company policies, GLP, IACUC, and animal welfare guidelines, including accurate documentation in laboratory notebooks and electronic records. Collaborate effectively within the immediate team and cross-functionally to advance program objectives. Demonstrate initiative and technical expertise in troubleshooting experimental issues and ensuring accurate data analysis. May involve working outside standard business hours, including weekends, holidays, and early mornings, to support critical in vivo studies and project deadlines. Education and Experience B.Sc. with 3-4+ years of experience or M.Sc. with 1-2+ years of experience in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline. Prior hands-on experience in pre-clinical drug discovery programs (industrial or academic settings) is strongly preferred. Prior experience working with radioactive materials is preferred. Prior experience culturing and expanding cancerous cell lines is a plus. Skills Technical proficiency in rodent handling (immune-compromised and -competent mice), aseptic procedures, and lab animal research. Ability to perform IV compound administration and SC engraftment is mandatory. Working knowledge of MS 365 and GraphPad Prism. Strong work ethic, self-motivation, adaptability, and organizational skills. Ability to work in a fast-paced, dynamic, and collaborative environment. Excellent written, oral communication, and presentation skills. Experience with in vivo imaging modalities is a plus. Familiarity with the drug development process and interdisciplinary teamwork. Uses AI tools to enhance individual productivity and quality of work Physical Demands & Work Environment Regularly required to sit, reach with hands and arms, and communicate effectively. Must occasionally lift and/or move up to 30–50 pounds. Specific vision abilities required: close vision and distance vision. Laboratory and vivarium environment with radioactive and biohazard materials; protective clothing, gloves, and safety glasses are mandatory at all times. Noise level is typically moderate. If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: San Diego - RayzeBio - CA: $95,505 - $115,730 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/. Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include: Health Coverage: Medical, pharmacy, dental, and vision care. Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. ​Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown. *Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program. RayzeBio and Bristol Myers Squibb RayzeBio was acquired by Bristol Myers Squibb (BMS) in 2024 and is a wholly-owned subsidiary