Senior Scientist, Respiratory Discovery (Biology & Translational Models)

Job description

Job Description The Senior Scientist will join the Respiratory Biology Discovery group and contribute to target identification, target validation, translational biology, and mechanism-of-action studies supporting early discovery programs across chronic lung diseases, including COPD, bronchiectasis, asthma, pulmonary fibrosis, and inflammatory airway disorders. The successful candidate will leverage advanced human-relevant in vitro, ex vivo, and tissue-engineered model systems to generate mechanistic and translational datasets that inform target prioritization and therapeutic strategy. Expertise in primary airway and alveolar epithelial biology, multicellular disease models, epithelial-stromal-immune interactions, tissue remodeling, regeneration, and biomarker discovery is highly desirable. The scientist will collaborate closely with multidisciplinary teams spanning biology, bioengineering, computational biology, translational sciences, and clinical research. Key Responsibilities: Design experimental strategies to interrogate epithelial, stromal, vascular, and immune-cell interactions driving chronic lung disease pathogenesis. Develop and apply disease‑relevant experimental systems, including primary airway epithelial cultures, air‑liquid interface (ALI) models, organoid systems, precision-cut lung slices (PCLS), and co-culture platforms. Generate mechanistic datasets to investigate epithelial dysfunction, tissue remodeling, fibrosis, immune responses, and regenerative biology in chronic lung diseases. Utilize imaging, transcriptomic, proteomic, and spatial profiling approaches to support target validation and translational hypothesis generation. Support translational biomarker discovery and validation using patient-derived samples and multiplex biomarker platforms (Luminex, Olink, AlphaLISA). Partner with computational biology and translational teams to integrate multi-omics datasets and identify disease-relevant pathways and biomarkers. Support evaluation of biologics, small molecules, and emerging therapeutic modalities using human disease-relevant model systems. Synthesize and interpret complex biological datasets to support target prioritization, mechanism-of-action studies, and portfolio decision-making. Collaborate closely across biology, pharmacology, DMPK, and translational and clinical teams within a matrixed discovery environment QUALIFICATIONS: Education: Ph.D. in Biology, Immunology, Pulmonary Biology, Bioengineering, Pharmacology, Cell Biology, Regenerative Medicine or related discipline and relevant experience Required Experience and Skills: Demonstrated expertise in respiratory biology and human primary cell-based systems, including airway and/or alveolar epithelial models Strong experience with ALI cultures, organoids, co-culture systems, tissue-engineered models, organ-on-chip platforms, and/or precision-cut lung slices Experience in target validation and translational biology within respiratory, immunology, fibrosis, regeneration, or related therapeutic areas Expertise with imaging-based approaches including IHC, IF, ICC, confocal microscopy, high-content imaging, image analysis, and quantitative phenotyping Ability to independently design, execute, troubleshoot, and interpret complex experimental studies Strong scientific communication skills and ability to present findings in cross-functional settings Preferred Experience and Skills: Prior experience in respiratory drug discovery, fibrosis, tissue remodeling, regenerative biology, or inflammatory lung disease research Experience with macrophage, fibroblast, epithelial, or immune-stromal co-culture systems Experience working with patient-derived respiratory tissues and primary human lung cells Familiarity with transcriptomic datasets including bulk RNA-seq and single-cell RNA-seq Experience with organoid biology, human tissue-based models, or spatial biology approaches Knowledge of translational biomarker strategies and human disease-relevant endpoints #EligibleforERP Required Skills: Cell Culture Techniques, Image Analysis, Immunocytochemistry (ICC), Immunohistochemistry (IHC), Organoid Culture, Pulmonary Disease Research, Pulmonary Disorders, Pulmonary Fibrosis Treatment, Target Validation Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement​ We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts The salary range for this role is $131,400.00 - $206,800.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits. You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. 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