Scientist - RNA Sciences & Preclinical Manufacturing

Job description

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. In its commitment to enhancing global health, BMS will unleash the full potential of RNA medicines to treat human disease in ways that were not previously possible. To achieve this vision, BMS is developing a best-in-class RNA platform that integrates established and emerging technologies with advanced delivery mechanisms to enhance the expression and durability of BMS’s novel RNA therapeutics and broaden delivery across cell types and tissues. Position Summary: We are seeking a Scientist to join the RNA Sciences and Preclinical Manufacturing team. This role sits at the interface of RNA/DNA research, process development, and preclinical material production in support of in vivo studies, platform development, and technology maturation. The successful candidate will be primarily responsible for developing and executing bench-scale manufacturing processes to produce preclinical-grade DNA and mRNA materials in support of discovery and preclinical programs. Because these materials may span diverse construct formats and production requirements, the role will require practical troubleshooting and targeted process development to enable reliable, fit-for-purpose material supply. The candidate may also support downstream, analytical, and molecular biology workflows, including sequencing and amplification-based methods to assess nucleic acid identity, abundance, and integrity in both standalone materials and biological samples. Position Responsibilities: In the role as a Scientist within the RNA Sciences and Preclinical Manufacturing team, the ideal candidate will: Develop and execute bench-scale manufacturing processes for preclinical-grade DNA and mRNA materials across diverse construct formats, using practical troubleshooting and targeted adjustments to meet quality, yield, and timeline needs. Support manufacturing goals through DNA molecular cloning, cell-based or cell-free production, and purification of DNA templates. Produce mRNA and circRNA using in vitro transcription and bench-scale purification methods. Partner with analytical and process development groups to develop and implement methods that improve production, purification, and quality assessment of DNA templates and RNA materials. Contribute to additional molecular biology, downstream, or analytical workflows as needed to support manufacturing objectives and platform development. Coordinate with teammates to prioritize production needs, maintain inventory records, and procure reagents needed for DNA and RNA production across multiple concurrent activities. Collaborate across RNA Sciences, Discovery Biology, and partner teams to accelerate BMS programs. EXPERIENCE Basic Qualifications: Bachelor’s Degree 5+ years of academic and / or industry experience Or Master’s Degree 3+ years of academic and / or industry experience Or Ph.D. or equivalent advanced degree in the Life Sciences Preferred Qualifications: B.S./M.S. in Biology/Biochemistry/Molecular Biology or related field with 4+ years of experience or a Ph.D. with 0-1 years of experience. Hands-on experience with plasmid DNA production and in vitro transcription of mRNA/circRNA is required. Experience developing and troubleshooting plasmid DNA workflows, including cloning strategy, construct verification, and DNA template preparation for RNA production, is highly desirable. Previous experience in performing analytics on RNA and DNA using chromatographic separation, capillary gel electrophoresis (CGE), qPCR, or sequencing is highly desirable. Experience using automated liquid handlers for nucleic acid production, purification, or analytical workflows is a plus. #LI-Onsite If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: Cambridge - MA - US: $128,380 - $155,571 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/. Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include: Health Coverage: Medical, pharmacy, dental, and vision care. Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. ​Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown. *Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique persp