Principal Statistician

Job description

Additional Job Description At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together. Find out more: Our approach to R&D Job title: Principal Statistician Location: Siena, Italy Employment type: Permanent, Full-Time Closing date for applications: 23 August 2026 Scope: Provide stat expertise to support the different study designs. Responsibilities This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following: Responsible for a whole study from design to execution for different study designs: Use stat methodology to establish study strategy (e.g.power modelling of different scenarios, set up power monitoring, set up mitigation plan to minimize risk of stat failure) Provide input to protocol (design, objective, endpoint, randomization strategy, sample size, stat analysis) Provide input to study set up (CRF review, randomization, DMP plan including specification for subset, important protocol deviation) Lead or contribute to Quantitative Decision Making activities, including development of Probability of Success assessments, simulation-based evaluations, scenario analyses and other quantitative approaches that support project, governance and portfolio decisions Develop SAP/AAR (involving sensitivity analysis to support robustness of result) and coordinate review Review the TFL, to coordinate review with the stat analyst, to approve the TFL Do the QC of the statistical analysis methodology Validate study specific dataset & analysis pgm specification Approve deviation from TFL format Propose SAR conclusion Prepare answer to study specific stat question (e.g. inspection, RA question) Provide stat support to an independent analysis center Provide consultancy on stat matter for other statisticians Why you? Basic Qualifications & Skills We are looking for professionals with these required skills to achieve our goals: Master Degree in Statistics, Mathematics, Epidemiology or equivalent, with at least 5-year experience in the pharmaceutical industry; OR PhD in Statistics, Mathematics or Epidemiology or equivalent with at least 2-year experience in the pharmaceutical industry. Experience in Statistical software (R preferred) and sample size computation for standard designs. Ability to work in multidisciplinary team (e.g. give guidance to non-stat, provide feedback, engage), some being remotely located. Good oral and written communication in English including ability to explain difficult issues and situations clearly and ensures meaning is understood. Fluent level of English, both written and spoken. Italian language skills are preferred Preferred Qualifications & Skills If you have the following characteristics, it would be a plus: Has been previously responsible for studies with different designs (dose range, superiority/non inferiority, futility rule,..) Strong communication skills, with the ability to explain complex statistical topics clearly Ability to collaborate effectively in cross-functional teams Problem-solving mindset and ability to handle complex situations Leadership and influencing skills, including the ability to guide and mentor others Attention to detail and strong quality focus Adaptability in a fast-paced, multicultural environment What we offer: Permanent contract in a very Inclusive environment Smart Working up to 50% for eligible roles Flexible Benefits Company Healthcare Plan Integrative pension fund Employee Assistance Programme Prevention services and vaccination clinic Tax assistance Local nursery agreement Postal service, laundry, shoe repair and tailoring On Site Gym On Site canteens and coffee corners Free company bikes and shuttle Please note that international relocation support cannot be provided; therefore, only candidates who are already based in the indicated country can be considered. Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. Skills Central Monitoring, Clinical Data Management, Clinical Development, Cross-Functional Teamwork, Data Acquisition (DAQ), Data Analysis, Data Governance, Data Standards, Decision Making, Digital Capabilities, Matrix Leadership, Problem Solving Italian Salary Range / Fascia retributiva in Italia: EUR 48,300 to EUR 80,500The annual gross base salary range for new hires in this position is listed above for each applicable location. These ranges take into account a number of factors including the candidate’s skills, experience, education level and the market rate for the role. In addition, this position may offer an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. More detailed information on the total benefits package will be supplied during the recruitment process. GSK/ViiV applies the National Collective Bargaining Agreement (NCBA) for employees in the chemical and chemical-pharmaceutical industry and, where applicable as a result of the role assigned and the related job classification, the National Collective Bargaining Agreement for Industrial Executives of companies producing goods and services. This role is available for applicants from multiple locations, and therefore salary ranges for certain locations are also shown. Salary ranges for other locations are shown because some markets have pay transparency laws that require salary information on job postings, and those locations are potential job sites for this role. If salary ranges are not displayed in the job posting for a specific location or country, the relevant compensation will be discussed during the recruitment process. Please note salaries vary by country based on the candidate’s skills, experience, education level and the market rate for the role. Offers are typically made within the advertised range based on the candidate’s skills, experience and qualifications, with the upper end generally reserved for highly experienced candidates or other exceptional circumstances aligned with these criteria.La fascia salariale della Retribuzione Annua Lorda (RAL) per i nuovi assunti in questa posizione è indicata sopra per ciascuna sede applicabile. Queste fasce tengono conto di diversi fattori, tra cui le competenze, l'esperienza, il livello di istruzione del candidato e le condizioni di mercato per il ruolo. Informazioni più dettagliate sull’intero pacchetto retributivo e sui benefit saranno fornite durante il processo di selezione. GSK/ViiV, applica il Contratto Collettivo Nazionale di Lavoro (CCNL) per gli addetti all’industria chimica e chimico-farmaceutica nonché, in relazione e come conseguenza del ruolo assegnato e della relativa qualifica, il Contratto Collettivo Nazionale di Lavoro (CCNL) dei Dirigenti Industria di aziende produttrici di beni e servizi. Questo ruolo è aperto a candidati basati in diversi paesi; per tale motivo sono indicate le fasce retributive relative a ciascun paese. La pubblicazione di tali fasce, per altri paesi, che sono possibili sedi lavorative per questa p