Scientist, High-Throughput Protein Expression and Purification

Job description

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it. Position Summary We are seeking a highly motivated Scientist to expand high-throughput biologics production capabilities within Discovery Biotherapeutics. This hands-on, laboratory-facing role will execute and advance scalable protein expression, purification, normalization, and characterization workflows that enable antibody, multispecific, and other biologics discovery programs. The successful candidate will bring practical experience in mammalian protein production and protein purification, with the ability to independently execute experiments, analyze data, troubleshoot workflows, and deliver high-quality protein reagents. The Scientist will work closely with Protein Sciences, Molecular Biology, Automation, Data Science, Discovery Biology, and project teams to align production activities with program priorities and experimental timelines. The ideal candidate thrives in a fast-paced, collaborative environment, enjoys solving technical challenges, and is motivated to apply automation and emerging technologies to improve throughput, reproducibility, and cycle time. Experience with laboratory automation, cell-free expression, workflow scripting, or closed-loop discovery is preferred. Key Responsibilities Execute high-throughput protein production workflows supporting antibody, multispecific, and other biologics discovery programs. Design, optimize, and troubleshoot transient mammalian expression workflows at micro- and mid-scale using HEK293, CHO, or related systems. Perform automated and semi-automated protein purification, sample normalization, and quality assessment to deliver fit-for-purpose protein reagents and therapeutic molecules. Operate, maintain, troubleshoot, and continuously improve liquid handlers, robotic workstations, automated purification systems, and associated analytical instrumentation. Develop robust, reproducible, and scalable workflows for protein expression, purification, normalization, and quality control. Plan and execute experiments, analyze and interpret scientific and operational data, document results, and communicate findings to cross-functional teams and project stakeholders. Partner with Protein Sciences, Molecular Biology, Automation, Data Science, Discovery Biology, and project teams to coordinate production requirements, priorities, and timelines. Evaluate and implement emerging technologies, instrumentation, miniaturization strategies, and automation solutions that improve throughput, quality, reproducibility, and operational efficiency. Establish and maintain best practices, standard operating procedures, quality standards, and documentation that support data integrity, reproducibility, and safe laboratory operations. Lead or contribute to root-cause analysis and resolution of workflow, production, and instrumentation issues, and implement corrective and preventive actions. Drive continuous-improvement initiatives that reduce cycle time, increase workflow reliability, and expand platform capabilities. Required Qualifications & Experience Bachelor's degree in biochemistry, bioengineering, structural biology, molecular biology, or a related scientific discipline with 5 or more years of relevant academic and/or industry experience; or a master's degree with 3 or more years of relevant experience; or a Ph.D. with no additional experience required. Hands-on experience with protein expression and production workflows in mammalian systems. Working knowledge of transient mammalian expression using HEK293, CHO, or related cell systems. Experience with protein purification technologies, including affinity chromatography, and with protein quality assessment methods. Molecular biology background, with a strong understanding of cloning and high-throughput DNA fragment generation. Ability to independently design and execute experiments, analyze data, troubleshoot technical problems, maintain accurate documentation, and advance assigned work. Ability to manage evolving priorities and timelines in a collaborative, matrixed research environment. Strong communication, collaboration, organizational, and problem-solving skills, with a clear commitment to laboratory safety and data integrity. Preferred Qualifications Experience executing high-throughput or plate-based protein expression, purification, normalization, and quality-control workflows across multiple concurrent requests or programs. Experience operating, maintaining, or troubleshooting laboratory automation platforms, liquid handlers, robotic workstations, automated purification systems, or integrated analytical instrumentation. Experience with analytical methods used for protein quality assessment, such as SEC, HPLC, SDS-PAGE, Octet, or related technologies. Experience with cell-free expression systems, miniaturized or low-volume expression formats, or other approaches that increase throughput while reducing material consumption. Familiarity with laboratory automation programming, workflow scripting, instrument integration, or scheduling and orchestration software. Working proficiency in Python, R, or comparable tools for data handling, workflow scripting, visualization, or analysis of production and quality-control datasets. Experience with ELN, LIMS, sample-registration systems, or structured digital data capture, including preparation of experimental data for downstream computational use. Experience collaborating with automation, data science, or computational teams in closed-loop, lab-in-the-loop, or model-in-the-loop discovery workflows. Experience with next-generation sequencing-coupled or display-based screening workflows and their interface with recombinant protein production. Experience contributing to workflow scale-up, technology implementation, operational metrics, root-cause analysis, or continuous-improvement initiatives. Experience developing or updating standard operating procedures, data standards, annotation conventions, or FAIR data practices. #LI-Onsite We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway. Compensation Overview: Brisbane - CA - US: $128,420 - $155,612 The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance. Benefits: Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability). U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year. Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subje