Biologics Process Research & Development , Senior Scientist

Job description

Job Description Biologics Process Research & Development (BPR&D) within our Company's Research Laboratories is on a mission to rapidly deliver biotherapeutics to patients by efficiently developing innovative, robust manufacturing processes and technologies. To achieve this, we work closely with colleagues in Discovery, Pre-clinical, Early Development, Analytical, Formulation, and Commercial Manufacturing while providing an inclusive environment for all. Beyond process development for pipeline biologics, we innovate and build next generation biomanufacturing technologies. Examples include investments for development of continuous manufacturing, green and sustainable processes, and proprietary technology platforms. We actively publish and engage with the scientific community to influence the field. Biologics Process Research & Development (BPR&D) includes three lab-facing technical functional areas: Process Cell Sciences (PCS), Upstream and Downstream Process Development & Engineering. The latter two together form our Biologics’ Process Development (BPD) group. This job posting covers opportunities for the BPD group. We are actively looking for highly motivated people with a passion for innovation and interest in contributing to upstream and/or downstream bioprocessing. Responsibilities include but are not limited to: Innovation Develop innovative and disruptive technologies for next-generation biologic manufacturing processes Apply rigorous scientific principles and data analyses to solve challenging problems related to developing robust, cost-effective processes Experimental Design and Problem-Solving Develop and characterize robust processes for delivering multi-kilogram quantities of life-changing medicines Design and conduct lab and/or pilot-scale studies to support mechanistic understanding, scale-up, and transfer of processes to manufacturing Collaboration and effective communication: Work with a collaborative, cross-functional team of talented scientists and engineers to advance the biologics pipeline from early- to late-stage development Partner with groups in both research and manufacturing divisions Represent your functional area in cross-functional teams Coaching and Mentoring Train and mentor junior scientists in experimental design, execution, and data interpretation Safety and Compliance Contribute to a safe and compliant laboratory work environment MINIMUM EDUCATION REQUIREMENTS: Bachelor's Degree with 4 years, or Master's Degree with 3 years or PhD with 0+ years of relevant experience (or expected PhD graduation within 6 months from date of application) in Chemical Engineering, Biochemical Engineering, Biomedical Engineering, Biotechnology, Biochemistry, Biology, Microbiology, or related fields REQUIRED EXPERIENCE AND SKILLS: A proven ability to design and execute hands-on lab and/or in silico experiments Proficiency with statistical design and analysis tools Excellent communication skills, ability to work in matrixed teams and collaborate with partners cross-functionally A demonstrated ability to think critically with excellent problem solving and troubleshooting skills In addition to the required skillsets above, relevant experience is needed in either upstream and/or downstream bioprocessing as described below. Upstream Knowledge of recombinant protein expression, metabolic pathways, biochemistry, and cell culture Understanding of basic bioreactor principles, mass transfer kinetics Understanding of cell & molecular biology Downstream Sound scientific knowledge of protein properties and purification Understanding of unit operations such as chromatography, filtration, crystallization, precipitation, adsorption, mixing etc. PREFERRED EXPERIENCE AND SKILLS: History of external presentations and/or publications in peer-reviewed journals Data science, modeling, machine learning, and artificial intelligence; proficiency with programming languages Evaluating and introducing novel technologies and analytical tools in process development and manufacturing Knowledge of protein biochemistry, biophysics, conjugation techniques Vector construction, Genetic Engineering, and Systems Biology Knowledge of cell-line development for protein expression in mammalian systems and suspension cell culture Hands-on experience with RNA and whole-genome (re)sequencing, and bioinformatics analysis High throughput experimentation using automation platforms Familiarity with feed and media development for large-scale recombinant protein expression in mammalian systems Knowledge of Quality by Design, Process Characterization and Control Strategy development #BPRD #PRD Required Skills: Biomanufacturing, Biomedical Engineering, Bioprocessing, Chemical Engineering, Data Analysis, Drug Delivery Technology, Flow Cytometry, High-Throughput Screening, Interpersonal Relationships, Microbiology, Molecular Biology Techniques, Molecular Microbiology, Multi-Color Flow Cytometry, Preformulation, Process Optimization, Production Process Development, Protein Biochemistry, Protein Expression, Protein Purifications Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement​ We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts U.S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”. The salary range for this role is $117,000.00 - $184,200.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and bus